The CMS AI Health Outcomes Challenge was the largest competition ever for healthcare AI with over 300 entrants and $1.6m in prize money. While many AI contests focus on accuracy, the CMS challenge emphasized explainability and “physician trust.” Challenge winner and ClosedLoop CEO, Andrew Eye, joined Graham Brooks, Partner at .406 Ventures, to discuss explainability in healthcare AI, the importance of domain expertise for AI project success, and CMS challenge takeaways.