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Learn how AI can help you promote early diagnosis, slow CKD progression, and anticipate and avoid complications and adverse events. See how AI helps to identify people with undiagnosed CKD or at-risk of rapid progression, predict adverse events due to poor medication adherence, predict CKD-related complications (e.g., hyperkalemia), or identify patients who are likely to initiate dialysis in the next year.

Automatically ingest data from dozens of health data sources including...

Electronic Health Records

EHR data with comprehensive patient histories of vital signs and symptoms, problem lists and chief complaints, tests results, diagnoses and procedures, and prescriptions.

Remote Monitoring Data

Remote monitoring data capture key vital signs and health behaviors (e.g. blood pressure, heart rate, blood glucose, activity levels, etc.).

Social Determinants of Health (SDoH)

Geo-centric data with details about the social and environmental influences on people’s health and outcomes.

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ClosedLoop generates explainable predictions using

thousands of auto-generated, clinically relevant contributing factors

Douglas English
67-Year-Old Male
Risk of rapid CKD progression in the next 12 months
Risk Score Percentile
Impact on Risk  |  Contributing Factor
+26% | Rise in Blood Pressure (mmHg)
130/85 to 150/100
+17% | Decline in eGFR (mL/min/1.73m2)
48 to 42
+12% | Low Adherence to HTN Medication
+8% | Pct With Limited Access to Healthy Foods

What Is CKD?

Chronic Kidney Disease (CKD) is a complex condition in which patients experience excessive cardiovascular and other adverse events and carry a heavy burden of morbidity, mortality, and healthcare costs. An estimated 37 million people—15% of adults—have CKD and another 20–25 million are at risk for developing it.¹

And yet, CKD remains under-recognized by providers and patients, especially in its early stages when patients are largely asymptomatic. Nine in ten adults with CKD are not aware of their condition and one in two people with extremely low kidney function do not know they have CKD.¹ Healthcare costs increase dramatically as CKD progresses and in later stages, are five to ten times higher than for someone without CKD.² These costs are primarily due to hospitalizations resulting from severe complications that often accompany reduced kidney function.

Why It Matters

Effective interventions can improve outcomes and reduce healthcare costs. For example, an intervention among beneficiaries of a Maryland health plan reduced hospital admissions by 30 to 45% (depending on CKD stage), readmissions by more than 70%, and costs by 20%.³ To expand the use of value-based programs for CKD, CMS recently announced the Advancing American Kidney Health initiative designed to increase value-based models starting in 2020.⁴ AI-based models are ideally suited to help clinicians and care teams in value-based programs by identifying patients to help promote early diagnosis, slow CKD progression, and anticipate and avoid complications and adverse events.

Did You Know…

  • 660,000 people live with kidney failure⁵
  • 37 million adults in the U.S. have CKD, a number that has doubled each of the last two decades¹
  • 9 in 10 adults with mild-to-moderate CKD are not aware of their condition and 25% of them (who also have diabetes) will experience rapid progression within two years¹
Citations & Footnotes

1. USRDS. “2016 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States.” National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2016. United States Renal Data System. 2016 USRDS annual data report: Epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2016. 

2. Golestaneh, Alvarez L., et al. “All-Cause Costs Increase Exponentially With Increased Chronic Kidney Disease Stage.” The American Journal of Managed Care, vol. 23, no. 10 Suppl, 2017, pubmed.ncbi.nlm.nih.gov/28978205/. Accessed 5 June 2020. 

3. Vassalotti JA;DeVinney R;Lukasik S;McNaney S;Montgomery E;Voss C;Winn D. “CKD Quality Improvement Intervention With PCMH Integration: Health Plan Results.” The American Journal of Managed Care, vol. 25, no. 11, 2019, pubmed.ncbi.nlm.nih.gov/31747237/. Accessed 5 June 2020. 

4. “HHS To Transform Care Delivery for Patients with Chronic Kidney Disease | CMS.” Cms.Gov, Centers for Medicare & Medicaid Services, 10 July 2019, www.cms.gov/newsroom/press-releases/hhs- transform-care-delivery-patients-chronic-kidney- disease#:~:text=Today%2C%20delivering%20on%20President%20Trump’s,Medicare%20and%20M edicaid%20Innovation%20payment. Accessed 5 June 2020. 

5. National Institute of Diabetes and Digestive and Kidney Diseases. “Kidney Disease Statistics for the United States | NIDDK.” National Institute of Diabetes and Digestive and Kidney Diseases, 9 Mar. 2021, www.niddk.nih.gov/health-information/health-statistics/kidney-disease. Accessed 5 June 2020.

6. Go, Alan S., et al. “Contemporary Rates and Predictors of Fast Progression of Chronic Kidney Disease in Adults with and without Diabetes Mellitus.” BMC Nephrology, vol. 19, no. 1, 22 June 2018, bmcnephrol.biomedcentral.com/articles/10.1186/s12882-018-0942-1#ref-CR31, 10.1186/s12882- 018-0942-1. Accessed 30 Apr. 2020.

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President & CEO, Healthfirst
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ClosedLoop.ai’s healthcare expertise was a big deal to us. It didn’t take a lot to translate things, and they adapted their approach to create a predictive model for our unique interest in the data streams.

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We are extremely impressed with the predictive modeling capabilities the ClosedLoop platform has delivered. The ClosedLoop team has exceeded all defined goals and benchmarks set to date and we anticipate a substantial return on our investment as these predictions are operationally deployed.

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We wanted to use the product for population health and SDOH. The things we can do with the ClosedLoop.ai product are unlimited.

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Over the course of my career, there has never been an opportunity like this. The need for efficiency is a daunting challenge. The capacity of predictive AI technology drives our efficiency and will have a lasting impact on our ability to help PCPs improve the quality of health outcomes while reducing health disparities.

Dr. Jim Walton
President & CEO, Genesis Physicians Group

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