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Learn how AI can help HCOs to promote early detection of MetS, improve patient self-management to slow or prevent the development of chronic diseases, and reduce the incidence of adverse events. Discover how AI can help to identify at-risk patients, surface patient-specific insights to improve care management, and predict avoidable acute care utilization.

Automatically ingest data from dozens of health data sources including...

Vital Signs

Data indicating the status of the body’s vital and life-sustaining functions, with core vital signs including blood pressure, pulse, respiration rate, and body temperature.

EHR Problem Lists

Data capturing the most important problems facing a patient, when it occurred and when it was resolved, and lists other illnesses, injuries and factors that affect their health.

Lab Test Results

Data about important risk markers from tests used for diagnosis, monitoring therapy, or screening, with details about specific results and abnormal indicators.

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ClosedLoop generates explainable predictions using

thousands of auto-generated, clinically relevant contributing factors

Hugh Stevens
42-Year-Old Male
Risk patient will develop metabolic syndrome
Risk Score Percentile
Impact on Risk  |  Contributing Factor
+26% | Increase in Fasting Blood Glucose Levels (mg/dL)
80 to 105
+18% | BMI Level
+14% | Rise in Blood Pressure (mmHg)
130/90 to 150/100
+10% | Decline in Sleep Quality (episodes / week)
2 to 5

What Is Metabolic Syndrome?

Metabolic syndrome (MetS) is a clustering of risk factors, including central obesity, insulin resistance, dyslipidemia, and hypertension that increases the risk of cardiovascular disease threefold and the risk of type 2 diabetes fivefold.¹ People with MetS also often have other conditions, including excessive blood clotting and constant, low-grade inflammation throughout the body. MetS has also been associated with a plethora of cancers including breast, pancreatic, colon and liver cancer.²𝄒³ 


Why It Matters

Nearly one-third of U.S. adults—approximately 80 million people—meet the criteria for MetS.¹ Such a high prevalence and potential for adverse outcomes imposes an enormous clinical and economic burden. Healthcare costs for individuals with MetS are 60% higher, and increase by another 24% for each additional risk factor.⁴ In total, the annual healthcare costs for people with MetS is estimated to exceed $220 billion.⁵ And yet, public awareness of MetS is alarmingly low. In a study of people with diabetes or at elevated risk for developing it, less than 15% indicated they had heard of the condition.⁶  Increased awareness and identification is paramount; an additional 104 million people are at risk for developing MetS.¹

AI Presents an Opportunity

Fortunately, MetS is preventable and potentially reversible, but success depends on the ability to better identify people at risk for MetS and to individually-tailor medical treatments and health interventions that can improve outcomes. AI can help healthcare organizations (HCOs) identify individuals at-risk for developing MetS and provide critical insight into their specific risk factors. Predictive analytics can enable care teams to personalize interventions with self-management support, diet and exercise regimes, and greater continuity of care. 

Did You Know…

  • 80 million adults in the U.S. meet the criteria for MetS¹
  • 60% higher annual utilization and costs on average are associated with MetS²
  • 5x individuals with MetS are five times more likely to develop diabetes mellitus¹
Citations & Footnotes

1. Steinberg, Gregory B., et al. “Novel Predictive Models for Metabolic Syndrome Risk: A ‘Big Data’ Analytic Approach.” The American Journal of Managed Care, vol. 20, no. 6, Jun. 24. pp:221–228. Accessed 20 Mar. 2021. 

2. NHLBI. Metabolic Syndrome | NHLBI, NIH. Nih.gov. Published December 28, 2020. Accessed March 24, 2021. https://www.nhlbi.nih.gov/health-topics/metabolic-syndrome

3. O’Neill S, O’Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity Reviews. 2014;16(1):1-12. doi:10.1111/obr.12229

4. Boudreau, D.M., et al. “Health Care Utilization and Costs by Metabolic Syndrome Risk Factors.” Metabolic Syndrome and Related Disorders, vol. 7, no. 4, Aug. 2009, pp. 305–314, doi:10.1089/met.2008.0070. Accessed 21 Mar. 2021.

5. Yu, Yu, et al. “Air Pollution, Noise Exposure, and Metabolic Syndrome – a Cohort Study in Elderly Mexican-Americans in Sacramento Area.” Environment International, vol. 134, Jan. 2020, p. doi:10.1016/j.envint.2019.105269. Accessed 21 Mar. 2021.

6. Lewis, S. J., et al. “Self-Reported Prevalence and Awareness of Metabolic Syndrome: Findings from SHIELD.” International Journal of Clinical Practice, vol. 62, no. 8, 29 Apr. 2008, pp. 1168–1176, doi:10.1111/j.1742-1241.2008.01770.x. Accessed 21 Mar. 2021.

ClosedLoop is an exciting and important partner in our strategy to develop timely predictive insights through operationalized AI solutions that will drive member engagement and better health outcomes.

Pat Wang
President & CEO, Healthfirst

Our partnership with ClosedLoop adds the depth of AI to more accurately identify those patients who are most likely to benefit from our primary care interventions as well to evaluate these interventions and make more relevant and timely modifications to improve their effectiveness.

David Klebonis
Chief Operating Officer, PBACO

We are extremely impressed with the predictive modeling capabilities the ClosedLoop platform has delivered. The ClosedLoop team has exceeded all defined goals and benchmarks set to date and we anticipate a substantial return on our investment as these predictions are operationally deployed.

Cheryl Lulias
President & Executive Director, MHN

We’re able to store and operationalize analytics directly from ClosedLoop. That’s driving real value—it’s accelerated the implementation of key insights into clinical workflows and it allows us to more easily account for all of the different factors that influence intervention decisions.

Christer Johnson
Chief Analytics Officer, Healthfirst

At SWHR, our patient-centered network is committed to innovative care models that are value-based, high-quality, and data-driven. Because of our partnership with ClosedLoop, we’re better able to identify and act on the most impactful opportunities for our physician partners to improve patient results and reduce unnecessary costs.

Dr. Jason Fish
Chief Medical Officer & SVP, Southwestern Health Resources

We compared the ClosedLoop predicted spend to the spend predicted by a leading rules-based risk prediction engine and found that 75% of the time ClosedLoop was closer, and in most cases significantly closer, to the actual spend.

Phillip Bruns
Chief Technology Officer, CareATC

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